Recently the long-standing and richly funded theory of Alzheimers plaques was decisively debunked. It should have been debunked and defunded earlier. It wasn’t logical in the first place, and it consumed all the resources for twenty years with zero results.
A much more logical and obvious hypothesis is starting to yield logical and obvious RESULTS.
Memory is lost when neurons are lost. Making more neurons avoids memory loss.
Here’s another proof of the obvious concept, at least in mice.
Lazarov and colleagues confirmed the importance of newly formed neurons for memory formation by specifically inactivating them in the brains of AD mice. This reversed the benefits of boosting neurogenesis, preventing any improvement in the animals’ memory.
“Our study is the first to show that impairments in hippocampal neurogenesis play a role in the memory deficits associated with AD by decreasing the availability of immature neurons for memory formation,” Lazarov says. “Taken together, our results suggest that augmenting neurogenesis may be of therapeutic value in AD patients.”
The grantors are starting to shift their priority; this work was funded by National Institute on Aging.
How do you make new neurons? NO EXPENSIVE DRUGS NEEDED.
Just walk. That’s all.
Exercising the brain may help, but exercising the body is the key.
(Incidentally, Lazarov is a nice aptronym.)